Is this a weed?
This appears to be Japanese Hops (Humulus japonicus), an invasive annual in our area. https://www.marylandbiodiversity.com/view/2212
You can compare traits such as rough leaf texture and prickly stems with information on this page: https://www.invasiveplantatlas.org/subject.html?sub=10091
It should be relatively easy to pull up, though using gloves would be best.