Which hop disease and how to treat?
A few things can cause these symptoms, mite, virus or nutrient/water stress. To determin if they are mites you can flip over the leaves and look for VERY tiny mites and webbing (see here http://www.canr.msu.edu/hops/uploads/files/Two_spotted_spider_mite.pdf )
If you haven't done a soil test I would also do that and make sure your pH is in a good range and that you don't have any deficiencies. Hops take a lot of N and water--you can learn more about that here http://www.canr.msu.edu/hops/uploads/files/Michigan%20Hop%20Management%20Guide%202018.pdf
I would start by eliminating those two issues as a possibility.