Poison ivy can be handpulled wearing protective clothing to keep the oils in all parts of the plant off of your skin. Or large patches of poison ivy leaves can be sprayed with an herbicide when it is actively growing. Triclopyr and Glyphosate are two common herbicides used on poison ivy. Large vines climbing up trees should be cut with a hand saw to remove a section of the vine. This will stop flow of water from soil up to the plant. Treat any growth from the stump and roots with herbicide.
There are also goat herds to be rented out to eat fenced in areas of poison ivy. Check local farm supply stores in your area to find out if any are located near you.
Never burn poison ivy or removed parts of poison ivy as the smoke can be extremely toxic.
UConn Home and Garden Education Center