Hello Chuck,

Thanks for your question.

What makes glyphosate an extremely effective non-selective herbicide is that it moves to the roots efficiently. The result is the death of the root.

There are “home remedies” on the internet, several of which contain acetic acid (stronger than home vinegar) and salt, that are billed as natural herbicides. These work by burning (completely desiccating) the tissue above ground, but do nothing to kill the root. The same result may be obtained by using a torch to burn the tissue above ground. For juvenile annual weeds that are small and have not established extensive root growth these solutions may be effective. You should not expect much lasting effect on established weeds or perennial weeds. On these, you would need to apply and reapply every time regrowth occurs. Regrowing shoots will take energy out of the root. However, if you allow the regrowth to photosynthesize at all, you are allowing the root to regain its strength. Another downside of these home remedies is that extended use can adversely affect soil pH and salinity. These secondary effects can make it difficult to establish any other plant growth.

https://blogs.ifas.ufl.edu/lakeco/2020/03/26/vinegar-vs-glyphosate-for-weed-control/

https://extension.umd.edu/resource/vinegar-alternative-glyphosate/

So to answer your question, it depends. If the weeds you want to kill are young annuals, you may have success. I expect no long term effect on the lily of the valley.

I hope this helps.